Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | set01_ATM_minus_versus_ATM_plus |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_neg |
| GeneSet | NCI_TNF RECEPTOR SIGNALING PATHWAY |
| Enrichment Score (ES) | -0.49771434 |
| Normalized Enrichment Score (NES) | -2.16161 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.0655231E-4 |
| FWER p-Value | 0.0040 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IL5 | 11 | 22.605 | 0.0161 | No | ||
| 2 | CYCS | 42 | 17.128 | 0.0274 | No | ||
| 3 | CEBPB | 74 | 15.638 | 0.0374 | No | ||
| 4 | RAN | 122 | 13.946 | 0.0455 | No | ||
| 5 | YWHAQ | 140 | 13.364 | 0.0546 | No | ||
| 6 | BID | 260 | 11.198 | 0.0573 | No | ||
| 7 | CDK4 | 343 | 10.371 | 0.0612 | No | ||
| 8 | PARP1 | 500 | 9.020 | 0.0606 | No | ||
| 9 | MYC | 869 | 7.330 | 0.0491 | No | ||
| 10 | ASAH1 | 1017 | 6.831 | 0.0473 | No | ||
| 11 | FGR | 1144 | 6.449 | 0.0463 | No | ||
| 12 | GAS2 | 1339 | 5.938 | 0.0417 | No | ||
| 13 | XPO1 | 1342 | 5.926 | 0.0460 | No | ||
| 14 | E2F1 | 1414 | 5.788 | 0.0470 | No | ||
| 15 | MAPK1 | 1423 | 5.768 | 0.0508 | No | ||
| 16 | BLK | 1450 | 5.692 | 0.0538 | No | ||
| 17 | LMNB2 | 1739 | 5.181 | 0.0444 | No | ||
| 18 | KPNB1 | 1789 | 5.095 | 0.0459 | No | ||
| 19 | ATF1 | 1894 | 4.952 | 0.0447 | No | ||
| 20 | LRDD | 1968 | 4.847 | 0.0449 | No | ||
| 21 | PPARG | 1999 | 4.807 | 0.0471 | No | ||
| 22 | BAD | 2011 | 4.790 | 0.0501 | No | ||
| 23 | UBE2D3 | 2039 | 4.762 | 0.0524 | No | ||
| 24 | LMNB1 | 2084 | 4.716 | 0.0538 | No | ||
| 25 | BAX | 2201 | 4.543 | 0.0518 | No | ||
| 26 | IGF1 | 2262 | 4.457 | 0.0523 | No | ||
| 27 | PTPRK | 2304 | 4.414 | 0.0537 | No | ||
| 28 | NFATC2 | 2387 | 4.322 | 0.0531 | No | ||
| 29 | MAPKAPK2 | 2720 | 3.998 | 0.0407 | No | ||
| 30 | APP | 2740 | 3.986 | 0.0428 | No | ||
| 31 | SMPD3 | 2799 | 3.951 | 0.0430 | No | ||
| 32 | TP53 | 2880 | 3.885 | 0.0422 | No | ||
| 33 | LMNA | 2993 | 3.805 | 0.0398 | No | ||
| 34 | IL3 | 3065 | 3.756 | 0.0393 | No | ||
| 35 | PPARGC1A | 3371 | 3.518 | 0.0279 | No | ||
| 36 | CASP3 | 3387 | 3.501 | 0.0297 | No | ||
| 37 | CASP9 | 3432 | 3.473 | 0.0303 | No | ||
| 38 | FOSL1 | 3479 | 3.447 | 0.0307 | No | ||
| 39 | IL2RA | 3564 | 3.387 | 0.0293 | No | ||
| 40 | EIF4EBP1 | 3974 | 3.161 | 0.0128 | No | ||
| 41 | GNB2L1 | 4224 | 3.030 | 0.0035 | No | ||
| 42 | PRKCI | 4238 | 3.023 | 0.0052 | No | ||
| 43 | SLC3A2 | 4297 | 2.996 | 0.0047 | No | ||
| 44 | MAP2K3 | 4337 | 2.980 | 0.0051 | No | ||
| 45 | TCF3 | 4510 | 2.909 | -0.0007 | No | ||
| 46 | USF1 | 4723 | 2.825 | -0.0084 | No | ||
| 47 | HSPB1 | 4823 | 2.785 | -0.0109 | No | ||
| 48 | SMPD1 | 5130 | 2.677 | -0.0230 | No | ||
| 49 | POU2F1 | 5182 | 2.660 | -0.0234 | No | ||
| 50 | MAF | 5280 | 2.628 | -0.0259 | No | ||
| 51 | RIPK1 | 5284 | 2.628 | -0.0241 | No | ||
| 52 | MEF2C | 5401 | 2.593 | -0.0276 | No | ||
| 53 | LIMK1 | 5462 | 2.569 | -0.0285 | No | ||
| 54 | YWHAG | 5501 | 2.556 | -0.0283 | No | ||
| 55 | PIK3R1 | 6230 | 2.327 | -0.0602 | No | ||
| 56 | IFNG | 6243 | 2.320 | -0.0590 | No | ||
| 57 | EGR4 | 6366 | 2.287 | -0.0629 | No | ||
| 58 | HCK | 6566 | 2.233 | -0.0705 | No | ||
| 59 | PAK3 | 6721 | 2.192 | -0.0760 | No | ||
| 60 | MAP3K7 | 6975 | 2.124 | -0.0861 | No | ||
| 61 | RAC1 | 7002 | 2.119 | -0.0857 | No | ||
| 62 | NFKB1 | 7091 | 2.093 | -0.0882 | No | ||
| 63 | FASLG | 7259 | 2.047 | -0.0944 | No | ||
| 64 | PAWR | 7291 | 2.040 | -0.0943 | No | ||
| 65 | RPS6KA5 | 7337 | 2.027 | -0.0949 | No | ||
| 66 | CAV1 | 7552 | 1.974 | -0.1033 | No | ||
| 67 | TH | 7580 | 1.968 | -0.1031 | No | ||
| 68 | ESR1 | 7998 | 1.858 | -0.1210 | No | ||
| 69 | IRF4 | 8141 | 1.829 | -0.1262 | No | ||
| 70 | DFFB | 8197 | 1.814 | -0.1273 | No | ||
| 71 | RNF128 | 8389 | 1.773 | -0.1348 | No | ||
| 72 | DUSP8 | 8849 | 1.661 | -0.1548 | No | ||
| 73 | PDGFA | 9072 | 1.606 | -0.1638 | No | ||
| 74 | YES1 | 9129 | 1.594 | -0.1652 | No | ||
| 75 | ETV1 | 9162 | 1.584 | -0.1655 | No | ||
| 76 | CASP4 | 9626 | 1.479 | -0.1858 | No | ||
| 77 | AKAP5 | 9904 | 1.409 | -0.1975 | No | ||
| 78 | CALM1 | 10454 | 1.273 | -0.2219 | No | ||
| 79 | PRKCZ | 10572 | 1.242 | -0.2264 | No | ||
| 80 | CASP1 | 10705 | 1.212 | -0.2315 | No | ||
| 81 | PRKRA | 10837 | 1.178 | -0.2367 | No | ||
| 82 | TRADD | 11123 | 1.103 | -0.2490 | No | ||
| 83 | NRK | 11809 | 0.902 | -0.2799 | No | ||
| 84 | CALM2 | 11871 | 0.882 | -0.2821 | No | ||
| 85 | DUSP10 | 11980 | 0.847 | -0.2864 | No | ||
| 86 | CASP8 | 12035 | 0.830 | -0.2883 | No | ||
| 87 | EGF | 12295 | 0.756 | -0.2997 | No | ||
| 88 | IL4 | 12402 | 0.724 | -0.3041 | No | ||
| 89 | JUN | 12565 | 0.666 | -0.3110 | No | ||
| 90 | VIM | 13001 | 0.512 | -0.3307 | No | ||
| 91 | TBX21 | 13363 | 0.371 | -0.3471 | No | ||
| 92 | PIM1 | 13451 | 0.338 | -0.3508 | No | ||
| 93 | CSF2 | 13564 | 0.288 | -0.3558 | No | ||
| 94 | GZMB | 13821 | 0.160 | -0.3675 | No | ||
| 95 | SFN | 14174 | -0.015 | -0.3837 | No | ||
| 96 | PLA2G4A | 14318 | -0.105 | -0.3902 | No | ||
| 97 | CDC25B | 14334 | -0.116 | -0.3908 | No | ||
| 98 | REL | 14913 | -0.486 | -0.4171 | No | ||
| 99 | PTGS2 | 14970 | -0.509 | -0.4193 | No | ||
| 100 | SRC | 15241 | -0.705 | -0.4312 | No | ||
| 101 | CD40LG | 15266 | -0.717 | -0.4318 | No | ||
| 102 | MAP2K1 | 15741 | -1.040 | -0.4528 | No | ||
| 103 | MAP4K3 | 15752 | -1.048 | -0.4525 | No | ||
| 104 | TNF | 16079 | -1.307 | -0.4666 | No | ||
| 105 | RIPK2 | 16143 | -1.360 | -0.4685 | No | ||
| 106 | TSC2 | 16253 | -1.451 | -0.4724 | No | ||
| 107 | ACTA1 | 16437 | -1.605 | -0.4797 | No | ||
| 108 | PRKACA | 16598 | -1.752 | -0.4858 | No | ||
| 109 | CRADD | 16775 | -1.909 | -0.4925 | No | ||
| 110 | ATF6 | 16839 | -1.964 | -0.4939 | No | ||
| 111 | RPS6KA4 | 16863 | -1.997 | -0.4935 | No | ||
| 112 | TNIK | 16901 | -2.033 | -0.4937 | No | ||
| 113 | PRKCH | 16959 | -2.083 | -0.4948 | No | ||
| 114 | DIABLO | 16978 | -2.104 | -0.4941 | No | ||
| 115 | TRAF6 | 16980 | -2.105 | -0.4926 | No | ||
| 116 | AKT1 | 17066 | -2.193 | -0.4949 | No | ||
| 117 | MITF | 17114 | -2.231 | -0.4954 | No | ||
| 118 | PRKG1 | 17162 | -2.273 | -0.4959 | Yes | ||
| 119 | SMPD2 | 17174 | -2.284 | -0.4948 | Yes | ||
| 120 | MAP3K7IP1 | 17192 | -2.295 | -0.4939 | Yes | ||
| 121 | MAPK9 | 17214 | -2.310 | -0.4931 | Yes | ||
| 122 | CASP2 | 17228 | -2.323 | -0.4920 | Yes | ||
| 123 | ERC1 | 17266 | -2.356 | -0.4920 | Yes | ||
| 124 | CALM3 | 17354 | -2.438 | -0.4942 | Yes | ||
| 125 | MAPKAPK3 | 17357 | -2.443 | -0.4925 | Yes | ||
| 126 | MAP3K14 | 17377 | -2.462 | -0.4916 | Yes | ||
| 127 | FOXP3 | 17466 | -2.555 | -0.4937 | Yes | ||
| 128 | RALA | 17496 | -2.599 | -0.4932 | Yes | ||
| 129 | NUP214 | 17596 | -2.687 | -0.4957 | Yes | ||
| 130 | RFFL | 17612 | -2.699 | -0.4944 | Yes | ||
| 131 | MAP2K6 | 17632 | -2.723 | -0.4933 | Yes | ||
| 132 | CHUK | 17643 | -2.730 | -0.4918 | Yes | ||
| 133 | PAK1 | 17746 | -2.826 | -0.4944 | Yes | ||
| 134 | MAPK14 | 17811 | -2.903 | -0.4952 | Yes | ||
| 135 | RAB5A | 17834 | -2.930 | -0.4941 | Yes | ||
| 136 | MAP3K8 | 17860 | -2.954 | -0.4930 | Yes | ||
| 137 | MAPK3 | 17962 | -3.067 | -0.4954 | Yes | ||
| 138 | FKBP1A | 17973 | -3.076 | -0.4936 | Yes | ||
| 139 | MAPK11 | 18040 | -3.143 | -0.4944 | Yes | ||
| 140 | FKBP8 | 18055 | -3.159 | -0.4927 | Yes | ||
| 141 | TOP1 | 18087 | -3.196 | -0.4917 | Yes | ||
| 142 | NSMAF | 18173 | -3.297 | -0.4932 | Yes | ||
| 143 | CFL2 | 18201 | -3.329 | -0.4920 | Yes | ||
| 144 | FADD | 18270 | -3.402 | -0.4927 | Yes | ||
| 145 | BCL3 | 18305 | -3.430 | -0.4917 | Yes | ||
| 146 | MKNK1 | 18365 | -3.498 | -0.4918 | Yes | ||
| 147 | TNFRSF1B | 18378 | -3.515 | -0.4898 | Yes | ||
| 148 | IKBKG | 18397 | -3.530 | -0.4880 | Yes | ||
| 149 | SPHK2 | 18416 | -3.552 | -0.4863 | Yes | ||
| 150 | SYK | 18493 | -3.653 | -0.4871 | Yes | ||
| 151 | PRKCD | 18528 | -3.688 | -0.4859 | Yes | ||
| 152 | BAG4 | 18610 | -3.769 | -0.4869 | Yes | ||
| 153 | YWHAB | 18690 | -3.865 | -0.4877 | Yes | ||
| 154 | SREBF1 | 18780 | -3.970 | -0.4889 | Yes | ||
| 155 | ATM | 18851 | -4.077 | -0.4891 | Yes | ||
| 156 | APAF1 | 18861 | -4.099 | -0.4865 | Yes | ||
| 157 | PAK2 | 18865 | -4.102 | -0.4836 | Yes | ||
| 158 | CREB1 | 18962 | -4.227 | -0.4849 | Yes | ||
| 159 | GSN | 18966 | -4.229 | -0.4819 | Yes | ||
| 160 | PRKCA | 18987 | -4.255 | -0.4797 | Yes | ||
| 161 | ARRB2 | 19063 | -4.371 | -0.4800 | Yes | ||
| 162 | RAF1 | 19074 | -4.383 | -0.4772 | Yes | ||
| 163 | CTLA4 | 19075 | -4.385 | -0.4740 | Yes | ||
| 164 | NUMA1 | 19093 | -4.407 | -0.4715 | Yes | ||
| 165 | FOS | 19178 | -4.546 | -0.4720 | Yes | ||
| 166 | SRF | 19248 | -4.646 | -0.4718 | Yes | ||
| 167 | HBP1 | 19318 | -4.762 | -0.4715 | Yes | ||
| 168 | MAP3K12 | 19326 | -4.778 | -0.4683 | Yes | ||
| 169 | NR4A1 | 19386 | -4.872 | -0.4674 | Yes | ||
| 170 | SLC9A1 | 19431 | -4.942 | -0.4658 | Yes | ||
| 171 | DDIT3 | 19452 | -4.972 | -0.4631 | Yes | ||
| 172 | NFKB2 | 19492 | -5.020 | -0.4612 | Yes | ||
| 173 | KSR1 | 19515 | -5.056 | -0.4585 | Yes | ||
| 174 | CSNK1A1 | 19558 | -5.138 | -0.4566 | Yes | ||
| 175 | EIF4E | 19561 | -5.139 | -0.4529 | Yes | ||
| 176 | BIRC2 | 19566 | -5.145 | -0.4493 | Yes | ||
| 177 | DUSP1 | 19595 | -5.181 | -0.4468 | Yes | ||
| 178 | CBLB | 19603 | -5.196 | -0.4433 | Yes | ||
| 179 | ATF2 | 19713 | -5.352 | -0.4444 | Yes | ||
| 180 | IKBKB | 19718 | -5.359 | -0.4406 | Yes | ||
| 181 | CAMK4 | 19772 | -5.438 | -0.4391 | Yes | ||
| 182 | DFFA | 19838 | -5.547 | -0.4380 | Yes | ||
| 183 | CTSD | 19842 | -5.553 | -0.4340 | Yes | ||
| 184 | CYLD | 19870 | -5.610 | -0.4311 | Yes | ||
| 185 | PRF1 | 19877 | -5.627 | -0.4273 | Yes | ||
| 186 | YWHAZ | 19925 | -5.718 | -0.4252 | Yes | ||
| 187 | PTPN1 | 20053 | -5.976 | -0.4267 | Yes | ||
| 188 | GATA3 | 20113 | -6.093 | -0.4249 | Yes | ||
| 189 | YWHAH | 20180 | -6.225 | -0.4234 | Yes | ||
| 190 | BCL10 | 20231 | -6.352 | -0.4210 | Yes | ||
| 191 | MAP2K7 | 20261 | -6.417 | -0.4176 | Yes | ||
| 192 | MAP3K7IP2 | 20281 | -6.446 | -0.4138 | Yes | ||
| 193 | MAP2K2 | 20359 | -6.618 | -0.4124 | Yes | ||
| 194 | RELB | 20410 | -6.758 | -0.4098 | Yes | ||
| 195 | MAP3K3 | 20422 | -6.791 | -0.4053 | Yes | ||
| 196 | PIK3CA | 20532 | -7.036 | -0.4051 | Yes | ||
| 197 | FBXW11 | 20554 | -7.084 | -0.4009 | Yes | ||
| 198 | MAPKAPK5 | 20596 | -7.204 | -0.3975 | Yes | ||
| 199 | PTK2 | 20652 | -7.365 | -0.3946 | Yes | ||
| 200 | PRKCE | 20653 | -7.365 | -0.3891 | Yes | ||
| 201 | ELK4 | 20776 | -7.731 | -0.3891 | Yes | ||
| 202 | EP300 | 20781 | -7.751 | -0.3836 | Yes | ||
| 203 | PRKCQ | 20917 | -8.226 | -0.3837 | Yes | ||
| 204 | DUSP16 | 20921 | -8.252 | -0.3778 | Yes | ||
| 205 | CSNK2A1 | 20926 | -8.269 | -0.3719 | Yes | ||
| 206 | TRAF1 | 20992 | -8.556 | -0.3686 | Yes | ||
| 207 | MAP4K4 | 21016 | -8.644 | -0.3633 | Yes | ||
| 208 | TRAF2 | 21018 | -8.648 | -0.3570 | Yes | ||
| 209 | RELA | 21022 | -8.671 | -0.3507 | Yes | ||
| 210 | ITCH | 21112 | -8.974 | -0.3482 | Yes | ||
| 211 | RALB | 21174 | -9.233 | -0.3442 | Yes | ||
| 212 | MAPK8 | 21208 | -9.408 | -0.3388 | Yes | ||
| 213 | MADD | 21274 | -9.747 | -0.3347 | Yes | ||
| 214 | JUNB | 21298 | -9.897 | -0.3284 | Yes | ||
| 215 | FYN | 21301 | -9.911 | -0.3212 | Yes | ||
| 216 | SQSTM1 | 21318 | -9.993 | -0.3146 | Yes | ||
| 217 | ARHGDIB | 21340 | -10.120 | -0.3081 | Yes | ||
| 218 | CASP6 | 21352 | -10.205 | -0.3011 | Yes | ||
| 219 | EGR1 | 21359 | -10.247 | -0.2939 | Yes | ||
| 220 | BCL2 | 21371 | -10.300 | -0.2868 | Yes | ||
| 221 | CREBBP | 21411 | -10.605 | -0.2808 | Yes | ||
| 222 | MEF2A | 21429 | -10.782 | -0.2736 | Yes | ||
| 223 | MAP4K5 | 21442 | -10.831 | -0.2662 | Yes | ||
| 224 | GSK3B | 21455 | -10.935 | -0.2587 | Yes | ||
| 225 | MAP2K4 | 21466 | -10.991 | -0.2511 | Yes | ||
| 226 | TNFAIP3 | 21482 | -11.148 | -0.2436 | Yes | ||
| 227 | BIRC3 | 21517 | -11.412 | -0.2367 | Yes | ||
| 228 | NFATC1 | 21534 | -11.557 | -0.2290 | Yes | ||
| 229 | CCM2 | 21538 | -11.589 | -0.2206 | Yes | ||
| 230 | ADAM17 | 21578 | -12.035 | -0.2135 | Yes | ||
| 231 | GDI1 | 21614 | -12.478 | -0.2059 | Yes | ||
| 232 | STAT1 | 21656 | -13.091 | -0.1982 | Yes | ||
| 233 | LSP1 | 21678 | -13.330 | -0.1894 | Yes | ||
| 234 | TNFRSF1A | 21703 | -13.816 | -0.1803 | Yes | ||
| 235 | MEF2D | 21742 | -14.522 | -0.1713 | Yes | ||
| 236 | NFATC3 | 21743 | -14.538 | -0.1606 | Yes | ||
| 237 | NFKBIA | 21775 | -15.114 | -0.1510 | Yes | ||
| 238 | LCK | 21778 | -15.166 | -0.1399 | Yes | ||
| 239 | MAP3K1 | 21803 | -15.769 | -0.1294 | Yes | ||
| 240 | YWHAE | 21814 | -16.134 | -0.1180 | Yes | ||
| 241 | MAP4K2 | 21842 | -17.169 | -0.1066 | Yes | ||
| 242 | MALT1 | 21871 | -18.066 | -0.0946 | Yes | ||
| 243 | DGKA | 21928 | -24.490 | -0.0791 | Yes | ||
| 244 | EGR3 | 21930 | -24.862 | -0.0609 | Yes | ||
| 245 | EGR2 | 21933 | -25.685 | -0.0421 | Yes | ||
| 246 | SATB1 | 21934 | -28.181 | -0.0213 | Yes | ||
| 247 | CASP7 | 21938 | -29.718 | 0.0004 | Yes |
